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Initial side effects of SSRIs often
include mild nausea, loose bowel movements, anxiety, headache, and sweating.
They usually disappear after a few weeks. Individuals taking SSRIs for an
extended period of time may complain of weight gain. With some of the SSRIs, it
is not uncommon to have sexual dysfunction. This is a later side effect and may
remain until the medication is discontinued. For men, it may mean low desire,
difficulty achieving an erection, trouble ejaculating, or delayed ejaculation
(which is why this class of drugs is used in treating premature ejaculation).
For women, it may mean low desire, trouble lubricating, or difficulty having an
orgasm. Some people complain of sedation with these medications. It is usually
helpful to have them taken before bedtime if that occurs. An additional side
effect of the SSRIs is that patients occasionally report very vivid dreams.
The most harmful side effect, though
rare, is serotonin syndrome. It is most likely to occur if two or more
serotonergic medications are used simultaneously. Although there are isolated
examples of this syndrome with one SSRI, the most important combination of
drugs to avoid is that of an SSRI and an MAOI. Serotonin syndrome starts out
with lethargy, restlessness, confusion, flushing, sweating, tremor, and sudden
jerking of the feet. It can progress to increased temperature, generalized
muscle rigidity, kidney failure, and even death.
In general, however, the side effects
of the SSRIs are easier to tolerate than those of the tricyclics or the MAOIs.
SSRIs are also much safer to use and are less dangerous if someone overdoses on
them.
Source: The Anxiety Answer Book by: Laurie A. Helgoe, PhD, Laura R. Wilhelm, PhD, Martin J. Kommor, MD
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